Determinants of host HIV-1 suspectibility and R5 HIV-1 evolution

Thesis

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Titlepage

Contents

1 General Introduction

2 Biological and molecular aspects of HIV-1 coreceptor usage

3 No selection for CCR5 coreceptor usage during parenteral transmission of macrophagetropic syncytium-inducing Human Immunodeficiency Virus type 1

4 Decreasing sensitivity to RANTES neutralization of CCR5-using, non-syncytium-inducing virus variants in the course of Human Immunodeficiency Virus type 1 infection

5 Sensitivity of primary R5 HIV-1 to inhibition by RANTES correlates with sensitivity to small-molecule R5 inhibitors

6 Evolution of R5 HIV-1 gp120 in patients who do not develop X4 HIV-1 variants

7 Correlates of resistance to HIV-1 infection in homosexual men with high-risk sexual behaviour

8 Low level CD4⁺ T cell activation is associated with low susceptibility to HIV-1 infection

9 Low levels of Human Immunodeficiency Virus type 1 DNA in high-risk seronegative men

10 Determinants of host HIV-1 susceptibility and R5 HIV-1 evolution

References

Summary

Samenvatting

Dankwoord

Theses which go together with

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