Properties of human antibodies to factor VIII defined by phage display

Thesis

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Titlepage

Contents

CHAPTER 1 Introduction Factor VIII, factor VIII inhibitors, and phage display

CHAPTER 2 Human antibodies with specificity for the C2 domain of factor VIII are derived from VH1 germline genes

CHAPTER 3 Two classes of germline genes both derived from the VH1 family direct the formation of human antibodies that recognize distinct antigenic sites in the C2 domain of factor VIII

CHAPTER 4 Multiple VH genes are used to assemble human antibodies toward the A3 domain of factor VIII

CHAPTER 5 The missense mutation Arg593 ®Cys is related to antibody formation in a patient with mild hemophilia A

CHAPTER 6 Longitudinal analysis of factor VIII inhibitors in a previously untreated mild hemophilia A patient with an Arg593®Cys substitution

CHAPTER 7 Molecular analysis of human anti-factor VIII antibodies by V gene phage display identifies a new epitope in the acidic region following the A2 domain

CHAPTER 8 The primary structure and epitope map of the variable domains of factor VIII antibodies obtained from hemophilia A patients with inhibitors by V gene phage display

CHAPTER 9 General discussion

Summary/Samenvatting

CURRICULUM VITAE

NAWOORD

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