Peptide cyclisation promoted by supramolecular complex formation
| Authors | |
|---|---|
| Publication date | 21-01-2022 |
| Journal | Organic and Biomolecular Chemistry |
| Volume | Issue number | 20 | 3 |
| Pages (from-to) | 575-578 |
| Number of pages | 4 |
| Organisations |
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| Abstract |
Phenol ester activated dipeptides that are reluctant to ring-close have been cyclised with the aid of sterically shielding metallo-porphyrins avoiding unwanted intermolecular reactions. The binding of ZnTPP to the dipyridine-functionalised activating phenolic ester was studied by NMR titrations and modelling. Staudinger-mediated cyclisations in the presence of ZnTPP increased the yield of the cyclic dipeptide from 16% to 40%. |
| Document type | Article |
| Note | With supplementary file. |
| Language | English |
| Published at | https://doi.org/10.1039/d1ob02309h |
| Other links | https://www.scopus.com/pages/publications/85123573238 |
| Downloads |
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| Supplementary materials | |
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