Virus and host determinants of HIV-1 infection and AIDS pathogenesis

Thesis

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Titlepage

Table of Contents

1: General Introduction

2: Infectious cellular load in HIV-1-infected individuals and susceptibility of PBMC from their exposed partners to NSI HIV-1 as major determinants for HIV-1 transmission in homosexual couples

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4: Adaptation to promiscuous usage of chemokine receptors is not a prerequisite for HIV-1 disease progression

5: CCR5 cell-surface expression in relation to CCR5 genotype and the clinical course of HIV-1 infection

6: Temporal relationship between HIV-1 RNA levels in serum and cellular infectious load in peripheral blood

7: In vitro replication kinetics of HIV-1 variants in relation to virus load in long-term survivors of HIV-1 infection

8: Evolution of S1 and NSI biological virus clones in relation to replication kinetics during the course of HIV-1 infection

9: In vivo HIV-1 infection of CD45RA+CD4+T cells is established primarily by SI variants and correlates with the rate of CD4+ T cell decline

10: Differential coreceptor expression within CD45RA+ naive and CD45RO+ memory CD4+ T cells provide distinct cellular niches for independent NSI and SI HIV-1 evolution

11: General Discussion

Summary

Samenvatting voor niet-ingewijden

References

List of publications

Curriculum Vitae

Nawoord

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