The role of ceramide in apoptosis

Thesis

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Titlepage

Table of Contents

Chapter 1 General Introduction

Chapter 2 CD95/Fas-induced ceramide formation proceeds with slow kinetics and is not blocked by caspase-3 / CPP32 inhibition.

Chapter 3 CD95 (Fas/APO-1) induces ceramide formation and apoptosis in the absence of a functional acid sphingomyelinase.

Chapter 4 Ordering of ceramide formation, caspase activation, and mitochondrial changes during CD95- and DNA damage-induced apoptosis.

Chapter 5 Common regulation of apoptosis signaling induced by CD95 and the DNA-damaging stimuli etoposide and γ-radiation downstream from caspase-8 activation.

Chapter 6 Sphingomyelin hydrolysis to ceramide during the execution phase of apoptosis results from phospholipid scrambling and alters cell-surface morphology.

Chapter 7 Overexpression of a neutral sphingomyelinase (nSMase1) in Jurkat T cells: Effect on ceramide production and apoptosis sensitivity.

Chapter 8 Glucosylceramide synthase does not attenuate the ceramide pool accumulating during apoptosis induced by CD95 or anti-cancer regimens.

Chapter 9 Summarizing Discussion

Chapter 10 Ceramide Mass Analysis by HPLC

NEDERLANDSE SAMENVATTING

Curriculum vitae

List of Publications

Dankwoord

Abbreviations

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