Solid Phase Synthesis of Fumitremorgin-type Alkaloids based on Cyclization/Cleavage Strategy

Thesis

Cover

Titlepage

Table of Contents

List of Abbreviations

Chapter 1 Application of Cyclization/Cleavage Strategy in Solid Phase Synthesis

Chapter 2 Fumitremorgin-type Indole Alkaloids

Chapter 3 Solid Phase Synthesis of Fumitremorgin-type Indolyl Diketopiperazines

Chapter 4 Solid Phase Synthesis of Indolyl Hydantoins, Dihydropyrimidinediones and Diazepane-diones

Chapter 5 Cyclorelease-based Synthesis of Heterocycles Involving α,β-unsaturated or a-amino Aldehyde Building Blocks

Chapter 6 Screening of Fumitremorgin C analogs for inhibition of BCRP-mediated drug efflux

Chapter 7 Potent and specific inhibition of the Breast Cancer Resistance Protein multidrug transporter in vitro and in mice by a novel analog of Fumitremorgin C

Summary

Samenvatting

Nawoord

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