Natural history of hepatitis C virus among injecting drug users

Authors	M.G.H.M. Beld
Supervisors	J. Goudsmit
Award date	07-04-1999
Number of pages	148
Organisations	Faculty of Medicine (AMC-UvA)
Document type	PhD thesis
Note	Research conducted at: Infectieziekten
Language	English
Downloads	Thesis Cover Titlepage Contents Chapter 1: General introduction Chapter 2: Low levels of hepatitis C virus (HCV) RNA in serum, plasma, and peripheral blood mononuclear cells in injecting drug users during long antibody-undetectable periods prior to seroconversion Chapter 3: Different profiles of hepatitis C virus RNA loads following seroconversion among injecting drug users without correlation with HCV genotype and serum alanine aminotransferase levels Chapter 4: Quantitative antibody responses to structural (core) and non-structural (NS3, NS4, and NS5) hepatitis C virus (HCV) proteins among seroconverting injecting drug users: impact of epitope variation and relationship to detection of HCV RNA in bloo Chapter 5: Hepatitis C virus serotype-speciflc core and NS4 antibodies in injecting drug users participating in the Amsterdam cohort studies Chapter 6: Evidence that both HIV and HIV-induced immunodeficiency enhance HCV replication among HCV seroconverters Chapter 7: Reduction of NS3 and NS5 antibodies to hepatitis C virus and increase in HCV RNA levels in HIV-coinfected injecting drug users Chapter 8: General discussion Chapter 9 Chapter 9: Summary Chapter 9: Samenvatting Chapter 9: Publications Chapter 9: Nawoord Cover
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