Neutrophil cell death: mechanisms and regulation

Thesis

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Titlepage

Table of contents

Chapter I Introduction

Chapter II Granulocyte colony-stimulating factor inhibits the mitochondria-dependent activation of caspase-3 in neutrophils

Chapter III Tumor necrosis factor α induces a caspase-independent death pathway in human neutrophils

Chapter IV Intramitochondrial serine protease activity of Omi/HtrA2 is required for caspase-independent cell death of human neutrophils

Chapter V Functional characterization of mitochondria in neutrophils: a role restricted to apoptosis

Chapter VI Bid truncation, Bid/Bax targeting to the mitochondria and caspase activation associated with neutrophil apoptosis are inhibited by granulocyte-colony stimulating factor

Chapter VII Apoptotic neutrophils in the circulation of patients with glycogen storage disease type 1b (GSD1b)

Chapter VIII Neutrophils in Barth Syndrome (BTHS) avidly bind Annexin-V in the absence of apoptosis

Chapter IX General discussion

Chapter X Summary, Nederlandse samenvatting, Резюме (на русском языке)

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