Immune functions in untreated and treated multiple sclerosis patients

Authors	M.H.G. Rep
Supervisors	C.H. Polman F. Miedema
Cosupervisors	R.A.W. van Lier
Award date	02-03-1999
Number of pages	128
Organisations	Faculty of Medicine (AMC-UvA)
Document type	PhD thesis
Note	Research conducted at: Immunologie
Language	English
Downloads	Thesis (complete) Front cover Title pages Table of contents Chapter 1: Introduction Chapter 2: Functional defects in peripheral blood T cells of multiple sclerosis patients Chapter 3: Monocyte functions in multiple sclerosis Chapter 4: A pilot study investigating the effects of orally administered pentoxifylline on selected immune variables in patients with multiple sclerosis Chapter 5: Recombinant interferon-β blocks proliferation but enhances interleukin-10 secretion by activated human T cells Chapter 6: Interferon-β treatment enhances CD95 and interleukin-10 expression but reduces interferon-γ producing T cells in MS patients Chapter 7: Treatment with depleting CD4 monoclonal antibody results in a preferential loss of circulating naive T cells but does not affect IFN-γ secreting TH1 cells in humans Chapter 8: Disease activity in multiple sclerosis patients is associated with a decrease in circulating naive CD4pos T cells and an increase in TH1/TH2 ratio Chapter 9: Summary & general discussion Samenvatting List of publications
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