Anesthetic induced cardioprotection: from bench to bedside and retour

Thesis

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Title pages

Table of contents

Part I, chapter 1: General Introduction and outline of this thesis

Part I, chapter 2: Anaesthesia and myocardial ischemia/reperfusion injury

Part II, chapter 1: Morphine induces late cardioprotection in rat hearts in vivo: the involvement of opioid receptors and nuclear transcription factor κB

Part II, chapter 2: Physiological levels of glutamine prevent morphine-induced preconditioning in the isolated rat heart

Part II, chapter 3: Morphine induces preconditioning via activation of mitochondrial K-Ca channels

Part III, chapter 1: Isoflurane preconditions myocardium against infarction via release of free radicals

Part III, chapter 2: Intermitted pharmacological pretreatment by xenon, isoflurane, nitrous oxide, and the opioid morphine prevents tumor necrosis factor alpha-induced adhesion molecule expression in human umbilical vein endothelial cells

Part III, chapter 3: Xenon induces late cardiac preconditioning in vivo: a role for cyclooxygenase 2?

Part III, chapter 4: Effects of nitrous oxide on the rat heart in vivo: another inhalational anesthetic that preconditions the heart?

Part IV, chapter 1: Impact of preconditioning protocol on anaesthetic-induced cardioprotection in patients having coronary artery bypass surgery

Part V, chapter 1: The regulation of mitochondrial respiration by opening of mK(Ca) channels is age-dependent

Part V, chapter 2: Ischaemic preconditioning phosphorylates mitogen-activated kinases and heat shock protein 27 in the diabetic heart

Part V, chapter 3: Sevoflurane induced preconditioning: impact of protocol and aprotinin administration on infarct size and endothelial nitric oxide synthase phosphorylation in the rat heart in vivo

Part VI, chapter 1: Main conclusion

Part VI, chapter 2: General discussion

Part VI, chapter 3: Nederlandse samenvatting

Part VI, chapter 4: Duitse samenvatting

Part VII, appendix A: Acknowledgement

Part VII, appendix B: Bibliography

Part VII, appendix C: Curriculum vitae

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