Transplantation of the rat suprachiasmatic nucleus. Functional studies and ex vivo adenoviral vector-mediated gene transfer

Thesis

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Titlepage

Table of contents

Chapter 1: General introduction

Chapter 2: Circadian rhythmicity of vasopressin levels in the cerebrospinal fluid of suprachiasmatic nucleus-lesioned and -grafted rats

Chapter 3: Vasopressin-deficient suprachiasmatic nucleus grafts reinstate circadian rhythmicity in SCN-lesioned arhythmic rats

Chapter 4: Adenoviral vector-mediated gene transfer and neurotransplantation: possibilities and limitations in grafting of the fetal rat suprachiasmatic nucleus

Chapter 5: Long-term transgene expression in fetal rat suprachiasmatic nucleus neurografts following ex vivo adenoviral-mediated gene transfer

Chapter 6: Transgene expression in rat fetal brain grafts is maintained for 7 months after ex vivo adenoviral vector-mediated gene transfer

Chapter 7: Ontogeny of neurotrophin receptor trkC expression in the rat forebrain and anterior hypothalamus with emphasis on the suprachiasmatic nucleus

Chapter 8: Adenoviral vector-mediated expression of neurotrophin-3 increases the number of vasopressinergic and vasoactive intestinal polypeptidergic neurons in suprachiasmatic nucleus grafts

Chapter 9: Effect of adenoviral vector-mediated expression of neurotrophin-3 in suprachiasmatic nucleus transplants on restoration of circadian rhythmicity; preliminary results

Chapter 10 General discussion

Summary

Samenvatting

Dankwoord

Curriculum Vitae

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