Regio- and stereoselective multi-enzymatic aminohydroxylation of β-methylstyrene using dioxygen, ammonia and formate
| Authors | |
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| Publication date | 07-12-2019 |
| Journal | Green Chemistry |
| Volume | Issue number | 21 | 23 |
| Pages (from-to) | 6246-6251 |
| Number of pages | 6 |
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| Abstract | We report an enzymatic route for the formal regio- and stereoselective aminohydroxylation of β-methylstyrene that consumes only dioxygen, ammonia and formate; carbonate is the by-product. The biocascade entails highly selective epoxidation, hydrolysis and hydrogen-borrowing alcohol amination. Thus, β-methylstyrene was converted into 1R,2R and 1S,2R-phenylpropanolamine in 59–63% isolated yields, and up to >99.5 : <0.5 dr and er. |
| Document type | Article |
| Note | With supplementary file |
| Language | English |
| Published at | https://doi.org/10.1039/c9gc03161h |
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Regio- and stereoselective multi-enzymatic
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