Modelling the Interplay Between Chronic Stress and Type 2 Diabetes On-Set

Stress has become part of the day-to-day life in the modern world. A major pathological repercussion of chronic stress (CS) is Type 2 Diabetes (T2D). Modelling T2D as a complex biological system involves combining under-the-skin and outside-the-skin parameters to properly define the dynamics involved. In this study, a compartmental model is built based on the various inter-players that constitute the hallmarks involved in the progression of this disease. Various compartments that constitute this model are tested in a glucose-disease progression setting with the help of an adjacent minimal model. Temporal dynamics of the glucose-disease progression was simulated to explore the contribution of different model parameters to T2D onset. The model simulations reveal CS as a critical modulator of T2D disease progression.