Chronic hepatitis C: new diagnostic tools and therapeutic strategies

Thesis

Cover

Titlepage

Contents

Chapter 1: General introduction

Aims of the studies

Part I: Confirmatory test methods in hepatitis C infection

Part I: Confirmatory test methods in hepatitis C infection: Chapter 2: Detection of hepatitis C virus RNA: application to diagnostics and research, (literature review)

Part I: Confirmatory test methods in hepatitis C infection: Chapter 3: Reliability of the third-generation recombinant immunoblot assay for hepatitis C virus.

Part I: Confirmatory test methods in hepatitis C infection: Chapter 3 add: Incorrect diagnosis of hepatitis C virus with RIBA-3.

Part I: Confirmatory test methods in hepatitis C infection: Chapter 4: International collaborative study on the second EUROHEP HCV-RNA reference panel.

Part I: Confirmatory test methods in hepatitis C infection: Chapter 5: Characterization of the EUROHEP HCV-RNA plasma standards in a collaborative study.

Part I: Confirmatory test methods in hepatitis C infection: Chapter 6: Characterization of the quantitative HCV NASBA assay.

Part I: Confirmatory test methods in hepatitis C infection: Chapter 7: Stability of hepatitis C virus RNA during specimen handling and storage prior to NASBA amplification.

Part I: Confirmatory test methods in hepatitis C infection: Chapter 8: What is the meaning of an anti-HCV positive, HCV-RNA negative test result?

Part II: Treatment in hepatitis C infection

Part II: Treatment in hepatitis C infection: Chapter 9: Hepatitis C treatment, (literature review)

Part II: Treatment in hepatitis C infection: Chapter 10: Virological response patterns in chronic hepatitis C patients in a multicentre, randomized, controlled study assessing a 6-36 month IFN-2b treatment schedule.

Part II: Treatment in hepatitis C infection: Chapter 11: Formation of antibodies to factor VIII in patients with hemophilia A who are treated with Interferon for chronic hepatitis C.

Part II: Treatment in hepatitis C infection: Chapter 12: General discussion

Summary

Samenvatting

Nawoord

Cover