MRP2 and the defence against drugs and toxins

Authors	C.G. Dietrich
Supervisors	R.P.J. Oude Elferink
Cosupervisors	C. Gartung
Award date	03-06-2003
Number of pages	102
Publisher	s.l.: s.n.
Organisations	Faculty of Medicine (AMC-UvA)
Document type	PhD thesis
Note	Research conducted at: Infectieziekten
Downloads	Thesis Cover Titlepage Contents Abbreviations Summary / Samenvatting Chapter I General Introduction Chapter II Lack of UGT1 isoforms in Gunn rats changes metabolic ratio and facilitates excretion of the food-derived carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine Chapter III Mrp2-deficiency in the rat impairs biliary and intestinal excretion and influences metabolism and disposition of the food-derived carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) Chapter IV Increased bioavailability of the food-derived carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in Mrp2-deficient rats Chapter V Role of MRP2 and GSH in intrahepatic cycling of toxins Chapter VI Regulation of organic anion transporters in a new rat model of acute and chronic cholangitis resembling human primary sclerosing cholangitis Chapter VII Conclusions and perspectives Words of thanks
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