Endotoxin-induced effects in healthy humans

Endotoxin-induced effects in healthy humans

Authors	P.E.P. Dekkers
Supervisors	S.J.H. van Deventer
Cosupervisors	T. van der Poll
Award date	06-04-2000
ISBN	9090135936 9789090135939
Number of pages	178
Organisations	Faculty of Medicine (AMC-UvA)
Document type	PhD thesis
Note	Research conducted at: CLDO/Infectieziekten
Language	English
Downloads	Thesis Cover Titlepage Contents Chapter 1 Introduction Chapter 2 Endotoxin downregulates monocyte and granulocyte Interleukin 6 receptors without influencing gp130 expression in humans Chapter 3 Granulocyte-colony stimulating factor (G-CSF) receptors on granulocytes are down-regulated after endotoxin administration to healthy humans Chapter 4 Upregulation of monocyte urokinase plasminogen activator receptor during human endotoxemia Chapter 5 The effect of a metalloproteinase inhibitor (GI5402) on TNF and TNF receptors during human endotoxemia Chapter 6 The metalloproteinase inhibitor GI5402 inhibits endotoxin-induced soluble CD27 and CD16 release in healthy humans Chapter 7 Tissue factor pathway inhibitor (TFPI) dose-dependently inhibits coagulation activation without influencing the fibrinolytic and cytokine response during human endotoxemia Chapter 8 Tissue factor pathway inhibitor (TFPI) does not influence inflammatory pathways during human endotoxemia Chapter 9 IC14, an anti-CD14 antibody, inhibits endotoxin mediated symptoms and inflammatory responses in humans Chapter 10 Divergent roles of Tumor Necrosis Factor and Platelet Activating Factor in endotoxin-induced release of Monocyte Chemoattractant Protein 1 and Macrophage Inflammatory Protein 1 in chimpanzees Chapter 11 Summary and Conclusion, Samenvatting en Conclusie Addendum Dankwoord Stellingen behorende bij het proefschrift Cover
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Endotoxin-induced effects in healthy humans