HIV-1 replication in macrophages

Authors	N.A. Kootstra
Supervisors	F. Miedema
Cosupervisors	H. Schuitemaker
Award date	10-09-1999
Number of pages	131
Organisations	Faculty of Medicine (AMC-UvA)
Abstract	Lentiviruses such as the human immunodeficiency virus type 1 (HIV-1) are considered to be unique amongst the retroviruses due to their ability to replicate in macrophages, which are often referred to as non-dividing cells. The studies described in this thesis focus on the ability of HIV-1 to replicate in primary macrophages and the cellular conditions involved in this process.
Document type	PhD thesis
Note	Research conducted at: Infectieziekten en Immunologie
Language	English
Downloads	Front cover Title pages Contents 1: General introduction 2: Proliferation-dependent HIV-1 infection monocytes occurs during differentiation into macrophages 5: Proliferation-dependent replication in primary macrophages of macrophage-tropic HIV-1 variants 7: Diminished HIV-1 reverse transcription and nuclear transport in primary macrophages arrested in early G1 phase of the cell cycle 8: Reverse transcription of T cell-tropic, but not macrophage-tropic HIV-1 can be regulated by NFAT in macrophages 9: General discussion Summary Samenvatting List of publications Dankwoord Back cover
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