Heterogeneously reduced connexin43 expression, conduction velocity and action potential duration during heart failure : implications for arrhythmogenesis

Authors	R.F. Wiegerinck
Supervisors	J.M.T. de Bakker
Cosupervisors	R. Coronel
Award date	21-09-2006
Number of pages	166
Organisations	Faculty of Medicine (AMC-UvA)
Document type	PhD thesis
Note	Research conducted at: CRIA
Language	English
Downloads	Thesis Cover Titlepage Contents Chapter 1 Arrhythmia and sudden death mechanisms in heart failure and hypertrophy Chapter 2 An overview of electrophysiological changes in animal models and patients with heart failure Chapter 3 Larger cell size in rabbits with heart failure increases myocardial conduction velocity and QRS duration Chapter 4 Prolonged QT interval and ventricular refractoriness in rabbits with heart failure is due to decreased intercellular coupling Chapter 5 Heterogeneously reduced ventricular connexin43 is associated with transmural dispersion in conduction velocity and refractory periods, and with increased arrhythmogenesis in a rabbit model of heart failure Chapter 6 The effect of enhanced gap junctional conductance on ventricular refractoriness and conduction velocity in rabbits and humans with heart failure Chapter 7 Why are patients in a moderate stage of heart failure more vulnerable to reentrant arrhythmia than patients in the end- stage of heart failure? Chapter 8 Samenvatting Dankwoord Cover
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