Factor VIIa-induced signal transduction; possible explanations for tissue factor-associated events

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Stellingen behorend bij het proefschrift " Factor VIIa-induced signal transduction; possible explanations for tissue factor-associated events"

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Contents

Alphabetical List of Abbreviations

1 General Introduction

2 Factor VIIa-Tissue factor interaction mediates signaling via activation of Src-like kinases, phoshatidylinositol-3-kinase, and Rac

3 Regulation of the p21Ras-MAP kinase pathway by Factor VIIa

4 FVIIa/tissue factor interaction results in a tissue factor cytoplasmic domain-independent activation of protein synthesis, p70 and p90 S6 kinase phosphorylation

5 Factor VIIa:TF induces activation of the JAK/STAT pathway; inflammatory signaling via non-inflammatory receptors

6 Factor VIIa induces cell survival and adhesion independence; a possible explanation for Tissue Factor-mediated metastasis

7 In-silico Tissue Factor analysis; a 'bit-by-bit' comparison

8 A new phosphospecific cell-based ELISA for p42/p44 MAP kinase, p38 MAP kinase, c-Akt/PKB and CREB

9 Summary and Discussion Samenvatting voor iedereen Handen op elkaar voor jezelf List of publications Curriculum vitae Color figures

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