Higher order structure of the HIV-1 leader RNA: a case for RNA switches that regulate virus replication

Thesis

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Stellingen

Titlepage

CONTENTS

CHAPTER 1 Introduction: Structure and Function of the HIV-1 leader RNA

CHAPTER 2 Two alternating structures of the HIV-1 leader RNA

CHAPTER 3 Mutations in the TAR hairpin affect the equilibrium between alternative conformations of the HIV-1 leader RNA

CHAPTER 4 Multiple secondary structure rearrangements during HIV-1 RNA dimerization

CHAPTER 5 An HIV-1 infected individual with low viral load harbors a virus variant that exhibits an in vitro RNA dimerization defect

CHAPTER 6 The dimer initiation site hairpin mediates dimerization of the human immunodeficiency virus, type 2 RNA genome

CHAPTER 7 Regulated HIV-2 RNA dimerization by means of alternative RNA conformations

CHAPTER 8 Requirements for RNA heterodimerization of the human immunodeficiency virus type 1 (HIV-1) and HIV-2 genomes

CHAPTER 9 The apical loop of the HIV-1 TAR RNA hairpin is stabilized by a cross-loop base pair

CHAPTER 10 Evidence for a base triple in the free HIV-1 TAR hairpin

CHAPTER 11 On the importance of the primer activation signal for initiation of tRNA(lys3)-primed reverse transcription of the HIV-1 RNA genome

CHAPTER 12 Summary and discussion

Samenvatting

Appendices Full-colour figures

Acknowledgements

List of publications

Curriculum Vitae

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