Power in GWAS: lifting the curse of the clinical cut-off
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| Publication date | 2013 |
| Journal | Molecular Psychiatry |
| Volume | Issue number | 18 |
| Pages (from-to) | 2-3 |
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| Abstract | Although genome-wide association studies (GWAS), in general, facilitated important discovery of new biological knowledge about diseases,1, 2, 3 identified variants for psychiatric disorders explain little variation, and insight into the role of genes in highly heritable psychiatric traits remains poor.4, 5 Low statistical power is seen as the main reason for the failure to locate more variants, and has resulted in a call for larger samples. Our present study, however, shows that better use of (available) phenotypic information can also increase power considerably. |
| Document type | Article |
| Language | English |
| Published at |
https://doi.org/10.1038/mp.2012.65
(Final published version)
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