Individual variation in biotransformation: relation to styrene kinetics and solvent-induced neur

Authors	M.A.M. Wenker
Supervisors	F.A. de Wolff
Cosupervisors	S. Kezic A.C. Monster
Award date	05-04-2001
ISBN	9064645086 9789064645082
Number of pages	175
Organisations	Faculty of Medicine (AMC-UvA)
Document type	PhD thesis
Note	Research conducted at: Geneeskunde, AmCOGG
Language	English
Downloads	Thesis Cover Titlepage Contents Chapter 1 General Introduction Chapter 2 Gas chromatography-electron capture determination of styrene-7,8-oxide enantiomers Chapter 3 Metabolism of styrene in human liver in vitro: interindividual variation and enantioselectivity Chapter 4 Metabolism of styrene-7,8-oxide in human liver in vitro: Interindividual variation and stereochemistry Chapter 5 Determination of mandelic acid enantiomers in urine by gas chromatography and electron capture or flame ionisation detection Chapter 6 Stereochemical metabolism of styrene in volunteers Chapter 7 Metabolic capacity and interindividual variation in toxicokinetics of styrene in volunteers Chapter 8 PBPK modelling of styrene: interindividual variation and stereochemistry Chapter 9 Genetic susceptibility to chronic toxic encephalopathy Chapter 10 Summarising discussion Samenvatting Curriculum vitae Dankwoord Cover
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