Rapid diagnosis and drug resistance of Mycobacterium tuberculosis

Rapid diagnosis and drug resistance of Mycobacterium tuberculosis

Authors	H.R. van Doorn
Supervisors	C.M.J.E. Vandenbroucke-Grauls
Cosupervisors	E.J. Kuijper M.D. de Jong
Award date	13-05-2005
Number of pages	160
Organisations	Faculty of Medicine (AMC-UvA)
Document type	PhD thesis
Note	Research conducted at: Infectieziekten
Language	English
Downloads	Thesis Cover STELLINGEN Titlepage CONTENTS CHAPTER 1 General Introduction: History, Diagnosis, and Resistance of Mycobacterium tuberculosis CHAPTER 2 Comparison of COBAS Amplicor MTB (Roche), and aMTD (Gen-Probe), with and without a Silica-GuSCN Based DNA Isolation Protocol, with in-house Real-time PCR for Diagnosis of Pulmonary Tuberculosis CHAPTER 3 The Susceptibility of Mycobacterium tuberculosis to Isoniazid and the Arg Leu Mutation at Codon 463 of katG Are Not Associated CHAPTER 4 Mutations at Amino Acid Position 315 of katG Are Associated with High-Level Resistance to Isoniazid, Other Drug Resistance, and Successful Transmission of Mycobacterium tuberculosis in The Netherlands CHAPTER 5 INH-resistant Mycobacterium tuberculosis Strains with a Mutation at Amino Acid Position 315 of katG Are a More Dangerous Public Health Threat than Other INH-resistant Strains; a 10-years Experience in The Netherlands CHAPTER 6 Detection of a Point Mutation Associated with High-Level Isoniazid Resistance in Mycobacterium tuberculosis by Using Real-Time PCR Technology with 3'-Minor Groove Binder-DNA Probes CHAPTER 7 SUMMARY SAMENVATTING EPILOGUE DANKWOORD CURRICULUM VITAE PUBLICATIES Cover
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Rapid diagnosis and drug resistance of Mycobacterium tuberculosis