Neutralizing antibodies to the HIV-1 envelope glycoproteins

Authors	A.F. Labrijn
Supervisors	C.E. Hack
Cosupervisors	J.G. Huisman P. Parren
Award date	24-02-2004
ISBN	909017737X 9789090177373
Number of pages	118
Organisations	Faculty of Medicine (AMC-UvA)
Document type	PhD thesis
Note	Research conducted at: Immunologie
Downloads	Thesis Cover Titlepage Contents Abbreviations Chapter 1 Antibodies, Phage Display and Membrane proteins Chapter 2 Neutralizing epitopes of HIV-1 Chapter 3 Novel strategy for the selection of human recombinant Fab fragments to membrane proteins from a phage-display library Chapter 4 An antigenic and immunogenic comparison of membrane-associated and soluble recombinant Human Immunodeficiency Virus Type 1 envelope glycoproteins Chapter 5 Novel broadly cross-reactive HIV-1 neutralizing human monoclonal Fab selected for binding to gp120-CD4-CCR5 complexes Chapter 6 Access of antibody molecules to the conserved coreceptor binding site on glycoprotein gp120 is sterically restricted on primary HIV-1 Chapter 7 Crystal Structure of Broadly HIV-1-Neutralizing Fab X5 and Proposition of its Epitope Chapter 8 Broadly neutralizing antibodies targeted to the membrane-proximal external region of human immunodeficiency virus type 1 glycoprotein gp41 Chapter 9 General Discussion Summary Samenvatting Curriculum vitae Dankwoord Stellingen Cover
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