Fatty acid beta-oxidation in Saccharomices cerevisae: new insights with implications for human diseases

Thesis

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Titlepage

Contents

List of Abbreviations

Chapter 1 General introduction

Chapter 2 The membrane of peroxisomes in Saccharomyces cerevisiae is impermeable to NAD(H) and acetyl-CoA under in vivo conditions

Chapter 3 Peroxisomal ß-oxidation of polyunsaturated fatty acids in Saccharomyces cerevisiae: isocitrate dehydrogenase provides NADPH for reduction of double bonds at even positions.

Chapter 4 Molecular characterization of carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria in Saccharomyces cerevisiae and identification of a plasma membrane carnitine transporter, Agp2p.

Chapter 5 Functional analysis of mutant carnitine acylcarnitine translocase (CACT) identified in two CACT-deficient patients with distinct clinical presentation.

Chapter 6 Pex11p plays a primary role in medium-chain fatty acid oxidation, a process that affects peroxisome number and size in Saccharomyces cerevisiae.

Chapter 7 Identification of a peroxisomal ATP carrier required for medium-chain fatty acid ß-oxidation and normal peroxisomal proliferation in Saccharomyces cerevisiae.

Chapter 8 Fatty acid ß-oxidation in Saccharomyces cerevisiae: an overview.

Reference List

Summary

Dankwoord

List of publications

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