Employing epigenetics to augment protein expression in mammalian cells

thesis

Omslag

Titlepage

Contents

Chapter 1: General introduction

Chapter 2: Identification of anti-repressor elements that confer high and stable protein production in mammalian cells

Chapter 3: Targeting of a histone acetyltransferase domain to a promoter enhances protein expression levels in mammalian cells

Chapter 4: A novel, high stringency selection system allows screening of few clones for high protein expression

Chapter 5: Various expression augmenting DNA elements benefit from STAR-Select, a novel high stringency selection system for protein expression

Chapter 6: General discussion

Summary

Samenvatting

List of publications

Dankwoord