Cellular immunity driving HIV-1 evolution

Thesis

Title pages

Contents

Chapter 1: General introduction and outline of this thesis

Chapter 2: Replication competent HIV-1 quasispecies obtained via clonal virus isolation from peripheral blood mononuclear cells is genetically highly similar to the contemporaneous HIV-1 quasispecies in plasma

Chapter 3: Limited evolution of HIV-1 subtype B in the early phase of infection

Chapter 4: Molecular evolution of human immunodeficiency virus type 1 upon transmission between human leukocyte antigen disparate donor-recipient pairs

Chapter 5: Viral replication capacity as a correlate of HLA B57/B5801-associated nonprogressive HIV-1 infection

Chapter 6: A nonprogressive clinical course in HIV-infected individuals expressing human leukocyte antigen B57/5801 is associated with preserved CD8 T lymphocyte responsiveness to the HW9 epitope in Nef

Chapter 7: The relation between HLA B*5701, HCP5 and HIV-infection

Chapter 8: Persistence of HIV-1-specific CTL responses restricted by both protective and non-protective HLA alleles during HIV-1 disease progression

Chapter 9: Adaptation of HIV-1 to the human immune system at the population level is driven by protective HLA B alleles

Chapter 10: Recovery of viremic control after superinfection with pathogenic HIV type 1 in a long-term elite controller of HIV type 1 infection

Chapter 11: Evolution of CCR5 using human immunodeficiency virus type 1 in relation to CCR5Δ32 host genetic background

Chapter 12: The presence of the Trim5α escape mutation H87Q in the capsid of late stage HIV-1 variants is preceded by a prolonged asymptomatic infection phase

Chapter 13: Discussion : cytotoxic T lymphocyte responses in HIV-1-infected long-term nonprogressors : lessons for vaccine design

Summary

Samenvatting voor niet-ingewijden

List of publications

Dankwoord