Amiodarone and thyroid hormone receptors

Thesis

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Titlepage

Contents

CHAPTER 1 Introduction

CHAPTER 2 Desethylamiodarone is a noncompetitive inhibitor of the binding of thyroid hormone to the TRß1 protein

CHAPTER 3 Desethylamiodarone is a competitive inhibitor of the binding of thyroid hormone to the TRα1 protein

CHAPTER 4 Structure-function relationship of the inhibition of the 3, 5, 3'-triiodothyronine binding to the TRα1 and TRß1 by amiodarone analogues

CHAPTER 5 Effect of mutations in the TRß1 on the inhibition of T3 binding by desethylamiodarone

CHAPTER 6 Interaction between nuclear hormone receptors and co-activators analysed using a nonradioactive "pull-down" assay

CHAPTER 7 Desethylamiodarone interferes with the binding of co-activator GRIP-1 to the ß1-thyroid hormone receptor

CHAPTER 8 Dronedarone acts as a selective inhibitor of 3,5,3'-triiodothyronine binding to TRα1: in vitro and in vivo evidence

CHAPTER 9 General discussion

References

Summary

Samenvatting

Dankwoord

List of publications

Stellingen

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