Aetiology and treatment of venous thromboembolism

Thesis

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Titlepage

Contents

chapter 1 General Introduction and Outline of this Thesis

Part One: Aetiology

chapter 2 Hereditary and Acquired Thrombophilia

chapter 3 Prothrombin 20210A Mutation: a Mild Risk Factor for Venous but not for Arterial Thrombotic Disease and Pregnancy-related Complications: a Family Study

chapter 4 Elevated Levels of FVIII:c within Families are Associated with Increased Risk for Venous and Arterial Thrombotic Events

chapter 5 Co-segregation of Thrombophilic Disorders in Factor V Leiden Mutation Carriers; the Contributions of Factor VIII, Factor XI, TAFI and Lipoprotein (a) to the Absolute Risk of Venous Thromboembolism

chapter 6 Acquired and Inherited Thrombophilic Factors and the Risk for Residual Venous Thrombosis

chapter 7 Does the Location of Deep Venous Thrombosis of the Leg Determine the Risk of the Post-thrombotic Syndrome?

chapter 8 Oral Contraceptives and Cardiovascular Disease

Part Two: Treatment

chapter 9 Home Treatment of Deep Venous Thrombosis: From Research to Daily Practice

chapter 10 A Novel Long-acting Synthetic Factor Xa Inhibitor (SanOrg 34006) to Replace Warfarin for Secondary Prevention in Deep Venous Thrombosis. A Phase II Evaluation

chapter 11 High Rate of Skin Complications Due to Low-molecular Weight Heparins in Pregnant Women

Part Three: Social Aspects of Inherited Thrombophilic Disorders and Treatment

chapter 12 Social Aspects of Genetic Testing for Factor V Leiden Mutation in Healthy Individuals and Their Importance for Daily Practice

chapter 13 A Qualitative Study of Carriers' Perception of Having a Genetic Risk Factor for a Common Disease: Uncertainty, Control and Stigma

chapter 14 Treatment of Venous Thromboembolism with Vitamin K antagonists: Patients' Utilities and Treatment Trade-offs

Summary

Samenvatting

Acknowledgements

About the Author

Stellingen behorende bij het proefschrift

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