Immunohistochemical analysis of rheumatoid synovial tissue: methodologic and pathogenetic studies

Thesis

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Titlepage

CONTENTS

Chapter 1 GENERAL INTRODUCTION

Chapter 2 MICROSCOPIC MEASUREMENT OF CELLULAR INFILTRATION IN THE RHEUMATOID ARTHRITIS SYNOVIAL MEMBRANE: A COMPARISON OF SEMIQUANTITATIVE AND QUANTITATIVE ANALYSIS

Chapter 3 ANALYSIS OF THE CELL INFILTRATE AND EXPRESSION OF MATRIX METALLOPROTEINASES AND GRANZYME B IN PAIRED SYNOVIAL BIOPSY SPECIMENS FROM THE CARTILAGE-PANNUS JUNCTION COMPARED WITH OTHER SITES WITHIN THE KNEE JOINT IN PATIENTS WITH RHEUMATOID ARTHRITIS

Chapter 4 ANALYSIS OF THE CELL INFILTRATE AND EXPRESSION OF PRO-INFLAMMATORY CYTOKINES AND MATRIX METALLOPROTEINASES IN ARTHROSCOPIC SYNOVIAL BIOPSIES COMPARED TO SYNOVIAL SAMPLES FROM PATIENTS WITH END-STAGE DESTRUCTIVE RHEUMATOID ARTHRITIS

Chapter 5 ANALYSIS OF THE CELLULAR INFILTRATES AND EXPRESSION OF CYTOKINES IN SYNOVIAL TISSUE FROM PATIENTS WITH RHEUMATOID ARTHRITIS AND REACTIVE ARTHRITIS

Chapter 6 POOR EXPRESSION OF T CELL DERIVED CYTOKINES AND ACTIVATION AND PROLIFERATION MARKERS IN EARLY RHEUMATOID SYNOVIAL TISSUE

Chapter 7 p53 OVEREXPRESSION IN SYNOVIAL TISSUE FROM PATIENTS WITH EARLY AND LONGSTANDING RHEUMATOID ARTHRITIS COMPARED WITH PATIENTS WITH REACTIVE ARTHRITIS AND OSTEOARTHRITIS

Chapter 8 ANALYSIS OF SERIAL SYNOVIAL BIOPSIES IN PATIENTS WITH RHEUMATOID ARTHRITIS: DESCRIPTION OF A CONTROL GROUP WITHOUT CLINICAL IMPROVEMENT AFTER TREATMENT WITH INTERLEUKIN-10 OR PLACEBO

Chapter 9 THE EFFECTS OF INTERFERON- TREATMENT ON SYNOVIAL INFLAMMATION AND EXPRESSION OF METALLOPROTEINASES IN PATIENTS WITH RHEUMATOID ARTHRITIS

Chapter 10 SUMMARY AND DISCUSSION

SAMENVATTING

DANKWOORD

CURRICULUM VITAE

BIBLIOGRAPHY

APPENDIX

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