Built for the kill. Studies on the neutrophil NADPH oxidase

Thesis

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Titlepage

Contents

Chapter 1 General Introduction

Chapter 2 Generation of mutations on potential FAD-binding residues in flavocytochrome b558 by a novel site-directed mutagenesis approach.

Chapter 3 Deletion of leucine 61 in glucose-6-phosphate dehydrogenase leads to chronic nonspherocytic anemia, granulocyte dysfunction, and increased susceptibility to infections.

Chapter 4 Continuous translocation of Rac2 and the NADPH oxidase component p67phox during phagocytosis.

Chapter 5 Role of the Sspj protein in protecting Salmonella Typhimurium from killing by the phagocyte NADPH oxidase.

Chapter 6 Activation of the neutrophil NADPH oxidase in response to Salmonella infection by intracellular Toll-like receptor 4 signalling.

Chapter 7 Summary and Discussion

Chapter 8 Samenvatting

Dankwoord

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