Palladium-free and ligand-free Sonogashira cross-coupling
| Authors |
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| Publication date | 2004 |
| Journal | Green Chemistry |
| Volume | Issue number | 6 | 4 |
| Pages (from-to) | 215-218 |
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| Abstract | Copper nanoclusters catalyse the cross-coupling of alkynes and aryl halides to give the corresponding disubstituted alkynes. No palladium, ligand, or co-catalyst is needed, and products are isolated in good yields (80–85%) and high selectivity. The clusters are simple to prepare, stable and can be applied to a variety of iodo- and bromoaryls. Mechanistic pathways for homocoupling and cross-coupling of alkynes are examined by comparing the activity of different catalyst and co-catalyst combinations. The copper clusters show different catalytic properties than their homogeneous analogues. |
| Document type | Article |
| Language | English |
| Published at |
https://doi.org/10.1039/b401586j
(Final published version)
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