The spectrum of premature atherosclerosis: from single gene to complex genetic disorder

Thesis

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Stellingen behorende bij het proefschrift van Mieke D Trip

Titlepage

Contents

General Introduction

Part I: Premature Atherosclerosis in FH : a single gene disease

Part I: Premature Atherosclerosis in FH: a single gene disease

Chapter 1 Familiaire Hypercholesterolemie: cardiovasculaire complicaties op jonge leeftijd te verwachten en te voorkomen (een klinische les)

Chapter 2 Molecular genetic testing in Familial Hypercholesterolemia: spectrum of LDL receptor gene mutations in the Netherlands

Chapter 3 Differences in intima-media thickness in the carotid and femoral arteries in Familial Hypercholesterolemia heterozygotes with and without clinical manifestations of cardiovascular disease

Chapter 4 Effect of aggressive versus conventional lipid lowering on atherosclerosis progression in Familial Hypercholesterolaemia (ASAP): a prospective, randomised, double-blind trial

Chapter 5 Hs-CRP reduction with aggressive statin therapy is associated with regression of carotid IMT in patients with Familial Hypercholesterolemia

Chapter 6 Effect of atorvastatin (80mg) and simvastatin (40mg) on plasma fibrinogen levels and on carotid intima media thickness in patients with Familial Hypercholesterolemia

Chapter 7 Effects of simvastatin on coagulation, fibrinolysis and intima media thickness in patients with Familial Hypercholesterolemia

Chapter 8 A frequent mutation in the lipoprotein lipase gene (D9N) exacerbates the biochemical and clinical phenotype of Familial Hypercholesterolemia.

Part II: Premature atherosclerasis : a complex genetic disorder

Chapter 1 Platelet hyperreactivity and prognosis in survivors of myocardial infarction

Chapter 2 Platelet Gp IIIa PlA polymorphism; its relation to coronary artery disease and its response to aspirin

Chapter 3 Genetic variations of the haemostatic system as risk factors for arterial thrombotic disease

Chapter 4 The 20210G!’A mutation in the 3'-untranslated region of the prothrombin gene and the risk for arterial thrombotic disease

Chapter 5 Frequent mutation in the ABCC6 gene (R1141X) is associated with a strong increase in the prevalence of coronary artery disease.

Chapter 6 Thrombospodin mutations are not associated with premature atherosclerotic vascular disease

Chapter 7 Prevalence of hereditary haemochromatosis in premature atherosclerotic vascular disease

Chapter 8 The effect of a common methylenetetrahydrofolate reductase mutation on levels of homocysteine, folate, vitamin B12 and on the risk of premature atherosclerosis

Summary

Samenvatting

Dankwoord

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