Enantioselective Intramolecular Reductive Heck Reaction with a Palladium/Monodentate Phosphoramidite Catalyst
| Authors |
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| Publication date | 21-02-2017 |
| Journal | ChemCatChem |
| Volume | Issue number | 9 | 4 |
| Pages (from-to) | 551-554 |
| Number of pages | 4 |
| Organisations |
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| Abstract | A palladium-catalyzed enantioselective reductive Heck reaction of enones using monodentate phosphoramidite ligands is described. α,α,α’,α’-tetraaryl-1,3-dioxolane-4,5-dimethanol (TADDOL)-based phosphoramidites with palladium(II) acetate, and N-methyl dicyclohexylamine as reducing agent gives the reductive Heck product in high yields and enantioselectivities of up to 90 %. The solvent plays an important role and in diethyl carbonate, the chemo- and enantioselectivity appeared to be the highest. |
| Document type | Article |
| Note | Special Issue: GeCatS -- 50. Jahrestreffen Deutscher Katalytiker |
| Language | English |
| Published at | https://doi.org/10.1002/cctc.201601153 |
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Enantioselective Intramolecular Reductive Heck
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