Targeting the vessel wall in cardiovascular prevention

Targeting the vessel wall in cardiovascular prevention

Authors	M.C. Meuwese
Supervisors	J.J.P. Kastelein
Cosupervisors	E.S.G. Stroes H. Vink
Award date	10-09-2008
ISBN	9789085594024
Number of pages	262
Organisations	Faculty of Medicine (AMC-UvA)
Document type	PhD thesis
Note	Research conducted at: Universiteit van Amsterdam
Language	English
Downloads	Thesis Cover Stellingen Titlepage Contents General introduction and outline of the thesis PART 1 THE ENDOTHELIAL GLYCOCALYX : INITIAL STEPS IN TESTING A PROMISING CONCEPT Chapter 1 The endothelial glycocalyx: a potential barrier between health and vascular disease Chapter 2 Measuring endothelial glycocalyx dimensions in humans: a potential novel tool to monitor vascular vulnerability Chapter 3 Sulphated glycosaminoglycans restore glycocalyx barrier properties of cultured endothelial cells in hyperglycemia Chapter 4 Effect of sulodexide on endothelial glycocalyx and albumin permeability in type 2 diabetic patients Chapter 5 Tumor Necrosis Factor-α inhibition protects against endotoxin-induced endothelial glycocalyx perturbation Chapter 6 Partial recovery of the endothelial glycocalyx upon rosuvastatin therapy in patients with heterozygous familial hypercholesterolemia Chapter 7 Effect of chronic hyaluronidase infusion on atherosclerosis progression and kidney function in ApoE deficient mice Summary and perspectives PART 2 MYELOPEROXIDASE : TESTING AN UPCOMING BIOMARKER Chapter 8 Serum myeloperoxidase levels are associated with the future risk of coronary artery disease in apparently healthy individuals Chapter 9 Myeloperoxidase levels are not associated with carotid atherosclerosis progression in patients with familial hypercholesterolemia Chapter 10 Diabetes mellitus type 2 is associated with higher levels of myeloperoxidase Chapter 11 Myeloperoxidase is not associated with scintigraphic myocardial perfusion abnormalities in type 2 diabetic patients with mild stable anginal complaints Chapter 12 Increases in myeloperoxidase levels after exercise in myocardial perfusion scintigraphy are not induced by myocardial ischemia Summary and perspectives PART 3 ACYL COENZYME A:CHOLESTEROL ACYL TRANSFERASE INHIBITION : DISCARDING A NEW TARGET FOR THERAPY Chapter 13 And then there were acyl coenzyme A:cholesterol acyl transferase inhibitors… Chapter 14 Ultrasound measurements of carotid arterial walls and the progression and regression of atherosclerosis Chapter 15 Effect of ACAT inhibition on progression of carotid atherosclerosis in patients with familial hypercholesterolemia : The CAPTIVATE study Summary and perspectives General summary Samenvatting Acknowledgements/Dankwoord Publications Conference abstracts Co-authors and affiliations List of abbreviations
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Targeting the vessel wall in cardiovascular prevention