Interaction of intravenous immunoglobulines (IVIG) with Fcgamma-receptors: activation and inhibition of phagocyte functions

Thesis

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Titlepage

Contents

Chapter 1 Introduction

Chapter 2 Human intravenous immunoglobulin preparations degranulate human neutrophils in vitro

Chapter 3 Modulation of human neutrophil apoptosis by intravenous immunoglobulin in vitro.

Chapter 4 Vasoactive side effects of intravenous immunoglobulin preparations in a rat model and their treatment with recombinant platelet-activating factor acetyl hydrolase.

Chapter 5 Intravenous immunoglobulin preparations induce mild activation of neutrophils in vivo via triggering of macrophages. Studies in a rat model.

Chapter 6 Activation of granulocytes and the cytokine network in hypogammaglobulinemic patients receiving intravenous immunoglobulin (IVIG) preparatations.

Chapter 7 Fcγ-receptor II expression on neutrophils discriminates hypogammaglobulinemia patients with or without side effects upon IVIG infusion

Chapter 8 Therapeutic efficacy of intravenous immunoglobulin (IVIG) preparations depends on the IgG dimers: studies in experimental immune thrombocytopenia.

Chapter 9 Modulation of immune complex-mediated inflammation by intravenous immunoglobulins (IVIG) in a rat model.

Chapter 10 Accelerated autoantibody clearance by intravenous immunoglobulin therapy. Studies in experimental models to determine the magnitude and time course of the effect.

Summary and General discussion

Nederlandse samenvatting

Curriculum vitae

Nawoord

List of publications

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