A Short Covalent Synthesis of an All-Carbon-Ring [2]Rotaxane
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| Publication date | 05-05-2017 |
| Journal | Organic Letters |
| Volume | Issue number | 19 | 9 |
| Pages (from-to) | 2342-2345 |
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| Abstract | While the current supramolecular syntheses of [2]rotaxanes are generally efficient, the final product always retains the functional groups required for non-covalent preorganization. A short and high-yielding covalent-template-assisted approach is reported for the synthesis of a [2]rotaxane. A terephthalic acid template core preorganizes the covalently connected ring precursor fragments to induce a clipping-type cyclization over the thread moiety. Cleavage of the temporary ester bonds that connect the ring and thread fragments liberates the [2]rotaxane. |
| Document type | Article |
| Note | With supplementary file |
| Language | English |
| Published at | https://doi.org/10.1021/acs.orglett.7b00877 |
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