Novel anticoagulant and prohemostatic strategies

Thesis

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Titlepage

Contents

CHAPTER 1 GENERAL INTRODUCTION

CHAPTER 2 COMPARISON OF SUSTAINED ANTITHROMBOTIC EFFECTS OF INHIBITORS OF THROMBIN AND FACTOR Xa IN EXPERIMENTAL THROMBOSIS

CHAPTER 3 SUCCESSFUL ATTENUATION OF VENOUS THROMBUS GROWTH IN RABBITS AFTER THE ADMINISTRATION OF A NOVEL ORAL THROMBIN INHIBITOR

CHAPTER 4 A NOVEL DIRECT SPECIFIC THROMBIN INHIBITOR (S 18326) ATTENUATES THROMBUS GROWTH AND ENHANCES THROMBOLYSIS IN A RABBIT VENOUS THROMBOSIS MODEL

CHAPTER 5 A NOVEL LOW MOLECULAR WEIGHT INHIBITOR OF PAI-1 (XR5118) REDUCES POST-THROMBOLYSIS THROMBUS GROWTH AND PROMOTES ENDOGENOUS FIBRINOLYSIS IN RABBITS

CHAPTER 6 APOLIPOPROTEIN(A) ATTENUATES ENDOGENOUS FIBRINOLYSIS IN THE RABBIT JUGULAR VEIN THROMBOSIS MODEL IN VIVO

CHAPTER 7 ENHANCEMENT OF RABBIT JUGULAR VEIN THROMBOLYSIS BY NEUTRALIZATION OF FACTOR XI: IN VIVO EVIDENCE FOR A ROLE OF FACTOR XI AS AN ANTI-FIBRINOLYTIC FACTOR

CHAPTER 8 FIBRINOGEN-COATED ALBUMIN MICROCAPSULES REDUCE BLEEDING IN SEVERELY THROMBOCYTOPENIC RABBITS.

CHAPTER 9 THE ABILITY OF RECOMBINANT FACTOR VIIa TO GENERATE THROMBIN DURING INHIBITION OF THE TISSUE FACTOR/FACTOR VIIa COMPLEX IN HUMAN SUBJECTS

CHAPTER 10 ACTIVATION OF COAGULATION BY ADMINISTRATION OF RECOMBINANT FACTOR VIIA ELICITS INTERLEUKIN (IL)-6 AND IL-8 RELEASE IN HEALTHY HUMAN SUBJECTS

CHAPTER 11 RECOMBINANT ACTIVATED FACTOR VII: A UNIVERSAL HEMOSTATIC AGENT?

CHAPTER 12 REDUCTION OF PERIOPERATIVE BLOOD LOSS AND TRANSFUSION REQUIREMENT IN PATIENTS UNDERGOING TRANSABDOMINAL RETROPUBIC PROSTATECTOMY BY ADMINISTRATION OF RECOMBINANT ACTIVATED FACTOR VII

CHAPTER 13 SUCCESSFUL TREATMENT WITH RECOMBINANT FACTOR VIIA OF THERAPY-RESISTANT SEVERE BLEEDING IN A PATIENT WITH ACQUIRED VON WILLEBRAND DISEASE

Co-authors

Samenvatting

Dankwoord

Curriculum Vitae

Publications

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