The right ventricle under acute and chronic overload: early detection of right ventricular dysfunction

Thesis

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Titlepage

TABLE OF CONTENTS

1 Introduction and Outline

Outline of The Thesis

Part I RV FUNCTION UNDER CHRONIC PRESSURE AND VOLUME OVERLOAD IN ADULT CONGENITAL HEART DISEASE

2 DOBUTAMINE-INDUCED INCREASE OF RIGHT VENTRICULAR CONTRACTILITY WITHOUT INCREASED STROKE VOLUME IN ADOLESCENT PATIENTS WITH TRANSPOSITION OF THE GREAT ARTERIES: EVALUATION WITH MAGNETIC RESONANCE IMAGING

3 USEFULNESS OF MAGNETIC RESONANCE IMAGING DOBUTAMINE STRESS IN ASYMPTOMATIC AND MINIMALLY SYMPTOMATIC PATIENTS WITH DECREASED CARDIAC RESERVE FROM CONGENITAL HEART DISEASE (COMPLETE AND CORRECTED TRANSPOSITION OF THE GREAT ARTERIES AND SUBPULMONIC OBSTRU

4 COMPARABLE SYSTEMIC VENTRICULAR FUNCTION IN HEALTHY ADULTS AND PATIENTS WITH UNOPERATED CONGENITALLY CORRECTED TRANSPOSITION USING MRI DOBUTAMINE STRESS

5 PULMONARY VALVE REGURGITATION AGGRAVATES IMPAIRED RIGHT VENTRICULAR FUNCTION IN PATIENTS WITH CHRONIC RIGHT VENTRICULAR PRESSURE OVERLOAD

6 REGIONAL AND GLOBAL RIGHT VENTRICULAR DYSFUNCTION IN ASYMPTOMATIC OR MINIMALLY SYMPTOMATIC PATIENTS WITH CONGENITALLY CORRECTED TRANSPOSITION OF THE GREAT ARTERIES

7 ECG DETERMINANTS IN ADULT PATIENTS WITH CHRONIC RIGHT VENTRICULAR PRESSURE OVERLOAD DUE TO CONGENITAL HEART DISEASE: RELATION WITH PLASMA NEUROHORMONES AND MRI PARAMETERS

8 INCREASED BRAIN AND ATRIAL NATRIURETIC PEPTIDES IN PATIENTS WITH CHRONIC RIGHT VENTRICULAR PRESSURE OVERLOAD: CORRELATION BETWEEN PLASMA NEUROHORMONES AND RIGHT VENTRICULAR DYSFUNCTION

Part II RV FUNCTION UNDER ACUTE PRESSURE OVERLOAD (EARLY DETERMINANTS FOR RV DYSFUNCTION)

9 INCREASED BRAIN NATRIURETIC PEPTIDE AS A MARKER FOR RIGHT VENTRICULAR DYSFUNCTION IN ACUTE PULMONARY EMBOLISM

10 UTILITY OF A BRAIN NATRIURETIC PEPTIDE AS A MARKER FOR RIGHT VENTRICULAR DYSFUNCTION IN ACUTE PULMONARY EMBOLISM

11 PEPTIDE (BNP) AS A PREDICTOR OF ADVERSE OUTCOMES IN PATIENTS WITH PULMONARY EMBOLISM

12 COMBINED UTILITY OF BRAIN NATRIURETIC PEPTIDE AND CARDIAC TROPONINE T MAY IMPROVE RAPID TRIAGE AND RISK STRATIFICATION IN PATIENTS WITH PULMONARY EMBOLISM

13 DECREASED PLASMA NEUROHORMONES AND IMPROVED CARDIAC PERFORMANCE AFTER SURGICAL TREATMENT OF CHRONIC PULMONARY EMBOLISM

14 SUMMARY AND CONCLUSIONS: RIGHT VENTRICULAR FUNCTION IN CONGENITAL HEART DISEASE: NONINVASIVE QUANTITATIVE PARAMETERS FOR CLINICAL FOLLOW-UP

15 SAMENVATTING EN DANKWOORD

CURRICULUM VITAE

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