Role of nm23 in neuroblastoma. From genetic aberrations to pathways abnormalities

Thesis

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Titlepage

Contents

Summary and scope of this study

Chapter 1 Introduction

Chapter 2 Lack of interstitial chromosome 1p deletions in clinically-detected neuroblastoma.

Chapter 3 The N-myc and c-myc downstream pathways include the chromosome 17q genes nm23-H1 and nm23-H2.

Chapter 4 Nm23-H2 protects against drug-induced apoptosis in neuroblastoma by interfering with the mitochondrial route to apoptosis.

Chapter 5 MYCN and nm23-H1 protein expression are closely correlated and predict an adverse outcome in neuroblastoma.

Chapter 6 Samenvatting voor de leek.

Dankwoord

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