Mechanisms of decreasing HIV-1 specific CD8+ T cell activity during progression to AIDS

Thesis

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Titlepage

Table of contents

Chapter 1 Introduction

Chapter 2 Evidence that human CD8+CD45RA+CD27 cells are induced by antigen and evolve through extensive rounds of division

Chapter 3 Diversity of the TCRBV repertoire in HIV-1 infected patients reflects the biphasic CD4+ T-cell repopulation kinetics during HAART.

Chapter 4 T-cell expansions in lymph-nodes and peripheral blood in HIV-1 infected individuals: effect of antiretroviral therapy.

Chapter 5 Normalisation of the CD4 T-cell receptor repertoire after evolution of syncytium inducing HIV-1 variants.

chapter 6 T cell receptor diversity in HIV infection: Missing clones or dominant expansions

Chapter 7 Longitudinal phenotypic analysis of human immunodeficiency virus type 1-specific cytotoxic T lymphocytes: correlation with disease progression

Chapter 8 High viral burden in the presence of major HIV-specific CD8+ T cell expansions: evidence for impaired CTL effector function

Chapter 9 Virus-specific CD27¯ effector CD8+ T cells are associated with protection from disease in HIV-infection

Chapter 10 Persistent numbers of tetramer+ CD8+ T cells, but loss of IFNy+ HIV-specific T-cells precedes progression to AIDS.

Chapter 11 Variable CD8+ T cell responsiveness to HIV Gag epitopes presented by different HLA alleles

chapter 12 Kinetics of tetramer+ T cells and IFNy+ T cells specific for Human Immunodeficiency Virus and Epstein-Barr Virus during treatment of HIV-1 infection

Chapter 13 Evolution of HIV specific T cells during the course of HIV infection

References

Summary

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Curriculum Vitae

List of publications

Nawoord

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