Familial hypercholesterolemia. The determination of phenotype

Thesis

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Stellingen behorend bij het proefschrift

Titlepage

Contents

1 General introduction and outline of this thesis

2 Phenotypic variability in familial hypercholesterolemia: an update

3 The contribution of classical risk factors to cardiovascular disease in familial hypercholesterolemia, Data in 2400 patients

4 Diagnosing familial hypercholesterolemia The need for genetic testing A study in 2400 FH heterozygotes

5 Data collection from medical records: Guidelines for the physician-scientist

6 Cardiovascular disease risk and genetic variation, A study in 2000 familial hypercholesterolemia heterozygotes

7 Susceptibility genes for all-cause mortality from familial hypercholesterolemia: a large parent-offspring study

8 Genetic determinants of plasma HDL-cholesterol levels in familial hypercholesterolemia, A study in 1000 FH heterozygotes

9 The risk of hyperhomocysteinemia in patients with familial hypercholesterolemia

10 PON-1 levels, PON-1 genotype and prevalence of symptomatic cardiovascular disease in subjects with familial hypercholesterolemia

11 Summary

Samenvatting

Participating Lipid Clinics

Dankwoord

Curriculum Vitae

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