From conception to cognitive decline How the prenatal environment may shape late-life brain health

Thesis (complete) (Embargo up to 2026-09-06)

Front matter

Chapter 1: General introduction

Chapter 2: Shaping the risk for late-life neurodegenerative disease: A systematic review on prenatal risk factors for Alzheimer’s disease-related volumetric brain biomarkers

Chapter 3: Longitudinal changes in late-life brain health after prenatal exposure to the Dutch famine (Embargo up to 2026-09-06)

Chapter 4: Brain aging after prenatal undernutrition: Longitudinal BrainAGE estimations in the Dutch famine birth cohort (Embargo up to 2026-09-06)

Chapter 5: Sex-specific effects of prenatal undernutrition on resting-state functional connectivity in the human brain at age 68

Chapter 6: Prenatal famine exposure and late-life functional brain network connectivity: A longitudinal study (Embargo up to 2026-09-06)

Chapter 7: Do prenatal factors shape the risk for dementia?: A systematic review of the epidemiological evidence for the prenatal origins of dementia

Chapter 8: Exposure to the Dutch famine in early gestation and cognitive function and decline in older age

Chapter 9: Brain activity during Stroop task performance at age 74 after exposure to the Dutch famine during early gestation

Chapter 10: General discussion

English summary; Nederlandse samenvatting; List of publications; PhD portfolio; Dankwoord