Shaping the brain through experience: effects of stressful life events on hippocampal neurogenesis, morphology and function

Thesis

Front cover

Title pages

Contents

Preface

Chapter 1: General introduction

Chapter 2: Opposite effects of early maternal deprivation on neurogenesis in male versus female rats

Chapter 3: Early maternal deprivation affects dentate gyrus structure and emotional learning in adult females

Chapter 4: Severe early life stress hampers spatial learning and neurogenesis, but improves hippocampal synaptic plasticity and emotional learning under high stress conditions in adulthood

Chapter 5: Brief treatment with the glucocorticoid receptor antagonist mifepristone normalizes the reduction in neurogenesis after chronic stress

Chapter 6: General discussion

Addendum: Spatial learning in the Morris water maze reduces newborn cell survival in the rostral hippocampus but does not affect neurogenesis: a discussion of the current state of confusion

List of abbreviations

Nederlandse samenvatting

Dankwoord

Curriculum vitae

List of publications