High-resolution probing of cellular force transmission

Authors
  • C.F. Schmidt
Publication date 2009
Journal Physical Review Letters
Volume | Issue number 102 | 16
Pages (from-to) 168102
Organisations
  • Faculty of Dentistry (ACTA)
Abstract Cells actively probe mechanical properties of their environment by exerting internally generated forces. The response they encounter profoundly affects their behavior. Here we measure in a simple geometry the forces a cell exerts suspended by two optical traps. Our assay quantifies both the overall force and the fraction of that force transmitted to the environment. Mimicking environments of varying stiffness by adjusting the strength of the traps, we found that the force transmission is highly dependent on external compliance. This suggests a calibration mechanism for cellular mechanosensing.
Document type Article
Published at https://doi.org/10.1103/PhysRevLett.102.168102
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