Closing the loop, squaring the circle: Studies on insulin delivery, glucose monitoring and the artificial pancreas

This thesis focuses on the steps necessary to create a functional closed loop system. In part I of this thesis we investigate how the body reacts on a glucose load. We especially focus on ingestion of meals. In part II of this thesis we investigate the nuances and variability of insulin infusion, focussing on the differences in insulin infusion materials on insulin administration. In part III we investigate the accuracy of continuous glucose monitors (CGM), with a special focus on comparing CGM systems for use in a closed loop system. In part IV we investigate a closed loop prototype to provide glycaemic control using two different control algorithms.