Dehydrative Cross-Coupling Reactions of Allylic Alcohols with Olefins
| Authors |
|
|---|---|
| Publication date | 2014 |
| Journal | Chemistry - A European Journal |
| Volume | Issue number | 20 | 35 |
| Pages (from-to) | 10905-10909 |
| Organisations |
|
| Abstract | The direct dehydrative activation of allylic alcohols and subsequent cross-coupling with alkenes by using palladium catalyst containing a phosphoramidite ligand is described. The activation of the allyl alcohol does not require stoichiometric additives, thus allowing clean, wastefree reactions. The scope is demonstrated by application of the protocol to a series allylic alcohols and vinyl arenes, leading to variety of 1,4-diene products. Based on kinetic studies, a mechanism is proposed that involves a palladium hydride species that activates the allyl alcohol to form the allyl intermediate. |
| Document type | Article |
| Note | With supporting information |
| Language | English |
| Published at |
https://doi.org/10.1002/chem.201404026
(Final published version)
|
| Permalink to this page | |
