Reproductive fitness of the human Y chromosome

Thesis

Cover

Stellingen behorende bij het proefschrift

Titlepage

Contents

Chapter 1 Introduction

Chapter 2 The use of spermHALO-FISH to determine DAZ gene copy number

Chapter 3 Recombination between palindromes P5 and P1 on the human Y chromosome causes massive deletions and spermatogenic failure

Chapter 4 Polymorphism for a 1.6-Mb deletion of the human Y chromosome persists through balance between mutation and haploid selection

Chapter 5 A family of human Y chromosomes has persisted for millennia despite a deletion of half of the Azoospermia Factor c region

Chapter 6 Conserved large-scale organization of the human Y chromosome despite its inherent tendency for genomic rearrangements

Chapter 7 Summary and implications for clinical practice and future research

Appendix

Dankwoord

About the author

Cover