1. Efficacy of systemically applied moxifloxacin as an adjunctive in non-surgical treatment of periodontitis. 2. Adjunctive antimimicrobial therapy of advanced periodontitis: Long-term effects on disease progression and oral microbial colonization. 3. Suitability of parameters and study designs for clinically controlled studies to assess the efficacy of moutrinses. Report for: German Federal Ministry for Education and Research and the German Research Foundation