Delayed Microbial Cure of Lymphogranuloma Venereum Proctitis with Doxycycline Treatment

Open Access
Authors
  • H.J.C. de Vries
  • V. Smelov
  • J.G. Middelburg
  • J. Pleijster
  • A.G. Speksnijder
  • S.A. MorrĂ©
Publication date 2009
Journal Clinical infectious diseases
Volume | Issue number 48 | 5
Pages (from-to) E53-E56
Organisations
  • Faculty of Medicine (AMC-UvA)
Abstract Microbial cure of chlamydia proctitis (lymphogranuloma venereum [LGV] and non-LGV) with doxycycline treatment was evaluated by chlamydia DNA and RNA persistence in anal swab specimens. In LGV proctitis, RNA persisted for up to 16 days. In non-LGV chlamydia proctitis, DNA was undetectable after 7 days. These findings support the Centers for Disease Control and Prevention's treatment recommendation of a 21-day doxycycline regimen for LGV proctitis and a 7-day regimen for non-LGV chlamydia proctitis. Delayed microbial cure of LGV proctitis should be considered in improved treatment regimens
Document type Article
Published at https://doi.org/10.1086/597011
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